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Without the natural ligand for the GHSR1a in many parts of the brain, the various roles of this receptor centrally remain uncertain
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Because of the chemical differences in the steroid core ring, testosterone and finasteride adopt different binding poses relative to NADPH, so that the ∆ 4,5 bond in testosterone and the ∆ 1,2 bond in finasteride can be reduced by SRD5A2 to generate distinct end products
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