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Several combinations with more mechanistic logic can be considered: First, for patients with βhigh mitochondrial oxidative stress load,β MitoQ or CoQ10 combined with long-acting bronchodilators/inhaled corticosteroids could be explored to control airway symptoms and inflammation with standard inhaled therapy while reducing mtROS and mitochondrial damage through MTAs (243, 244)
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In this regard, superoxide dismutase (SOD) has been found to protect plants from superoxide anions (O 2 Β· β ) by converting them into H 2 O 2 and O 2 under heavy metal stress (Thakur et al., 2017
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