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A double-blind RCT comparing patients treated with AZA and either prednisone 40mg daily tapered to 10mg daily or budesonide 3mg three times daily tapered to 3mg two times daily showed higher rates of serologic remission at six months (47% vs 18.4%, p 50% of patients

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In fact, experimental models have demonstrated that oxidative stress induces behavioural and molecular anomalies strikingly similar to those observed in schizophrenia