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Currently, endpoint measurements are related to severe cell damage such as tetrazolium reduction assay and lactate dehydrogenase (LDH) assay to detect viable cells and IL-1α release as inflammatory markers 21

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The particular arcade vessel presentation at specific subsequent time points [A (1 min before therapy), B (the first 5 min following therapy), C (the next 5 min, until the 10 th min), D (until the end of the 15 th min)] demonstrates how the obstructions in the tissues were bypassed